Accounting for Post-Transcriptional Regulation in Boolean Networks Based Regulatory Models
نویسندگان
چکیده
Boolean Networks are emerging as a simple yet powerful formalism to model and study Gene Regulatory Networks. Nevertheless, the most widely used Boolean Network-based models do not include any post-transcriptional regulation mechanism. In this paper we discuss how the post-transcriptional regulation mechanism mediated by miRNAs can be included in a Boolean Network based model. This contribution constitutes a key preparatory step in the study of the topological and structural role of miRNAs in complex regulatory networks.
منابع مشابه
Using Boolean networks to model post-transcriptional regulation in gene regulatory networks
Gene regulatory networks (GRNs) model some of the mechanisms that regulate gene expression. Among the computational approaches available to model and study GNRs, Boolean network (BN) emerged as very successful to better understand both the structural and dynamical properties of GRNs. Nevertheless, the most widely used models based on BNs do not include any post-transcriptional regulation mechan...
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